Abstract S ince Westphal 1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. This was striking to all observers, for the patient would now help in ward duties and could walk about without giddiness. Osteoporosis occurring during potassium thiocyanate therapy for hypertensive disease. From the Department of Pathology of Washington University School of Medicine and the St. Louis County Hospital. Skin Contact: Causes irritation to skin. Zietzer A, Niepmann ST, Camara B, Lenart MA, Jansen F, Becher MU, Andrié R, Nickenig G, Tiyerili V. PLoS One. NIH eCollection 2019. Since Westphal1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/, NLM 1947 Mar 15;1(6446):324-6. doi: 10.1016/s0140-6736(47)90137-2. 3. Solid Vapor Pressure Vapor Density Specific Gravity / Density <1 hPa @ 20 °C Not applicable 1.886 Solid Bulk Density 750 - 1000 kg/m 3 Water Solubility 2170 g/L (20°C) Terms of Use| Skin Contact: Causes irritation to skin. Potassium thiocyanate Revision Date Oct-2018 Evaporation Rate Flammability (solid,gas) Explosion Limits Not applicable No information available. 1947 May 3;1(4504):595-8. Measure 20 ml of water into the measuring cylinder and pour it into the beaker containing the iron(III) chloride. BLOOD PRESSURE DROP DURING THIOCYANATE ADMINISTRATION, AND BLOOD PRESSURE RISE AFTER WITHDRAWAL OF THE DRUG, IN THE FIFTY HYPERTENSIVE PATIENTS EXTENT OF FALL Fall during thiocyanate period (No. A diet rich in potassium is associated with a lower risk of high blood pressure, kidney stones and osteoporosis, among other benefits (8, 9, 10). It is an important salt of the thiocyanate anion, one of the pseudohalides.The compound has a low melting point relative to most other inorganic salts. Just like potassium, too much magnesium can be lost in urine due to diuretic use, leading to low magnesium levels. Furthermore, the pharmaceutical industry uses thiocyanic acid as a raw material for antibiotics, chemotherapeutic drugs, and thyroid medications. 1 Structures Expand this section. of patients) Rise during terminal placebo period (No. In addition to conditions like kidney disease, these factors also contribute to hyperkalemia: A high-potassium diet, which can result from potassium supplements and salt substitutes. A person’s potassium levels can affect their blood pressure. 1942;119(15):1177–1181. A dose level of 100 mg/kg bw per day (sodium or potassium salt) caused a progressive loss of weight, apathy, head droop, ataxia, and ultimate death.  |  Magnesium helps regulate hundreds of body systems, including blood pressure, blood sugar, and muscle and nerve function. 1949 Jul;11(3):249-56. doi: 10.1136/hrt.11.3.249. Low potassium levels can lead to an increase in blood pressure, particularly in people with a high sodium, or salt, intake. Cassava is the most important food source in the tropics after rice and maize (1). Also known as water pills or diuretics, these types of medications are often prescribed for people who have high blood pressure … doi: 10.1371/journal.pone.0214476. OSHA Vacated PELs: Potassium thiocyanate: No OSHA Vacated PELs are listed for this chemical. Proc Staff Meet Mayo Clin. The probable lethal dose is between 15-30 grams. XP-4750-100. Potassium thiocyanate is the chemical compound with the molecular formula KSCN. of patients) 6(12%) 20%p OR OVER 7 (14%) FALL TO RISE TO NORMAL INITIAL 2 (4%) 2 (4%) -- 11 (22%) I In the group of eleven patients in whom symptomatic relapse followed thiocyanate withdrawal, the blood pressure … By continuing to use our site, or clicking "Continue," you are agreeing to our, 2021 American Medical Association. blood. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Hypertensive headache treated with potassium thiocyanate. Potassium thiocyanate in the treatment of hypertension. PARSONNET AE, SIMON F, BERNSTEIN A. PMID: 14795149 [PubMed - indexed for MEDLINE] MeSH Terms. Contents. There are also data from a meta-analysis that showed that a 1.6-gram increase in potassium intake per day could lower risk of stroke by as much as 21%. Cases are then divided into four groups: 1. Barker2 in 1936 reported favorably on the use of thiocyanate for the treatment of hypertension and again3 in 1941 reaffirmed his opinion from a study of 246 patients observed for periods ranging from two to ten years. The thiocyanate ion [CNS—] was first used therapeutically in References That this opinion is shared by other clinicians and that the thiocyanate treatment of hypertension is becoming more generally used is seen from the number of recent publications to that effect.4 However, others have felt that thiocyanates were not only dangerous5 in the treatment of hypertension but useless.6 The toxic manifestations encountered in clinical practice with thiocyanate are well known and have been carefully considered by Wald7 and others. Potassium thiocyanate is the chemical compound with the molecular formula KSCN. Eating to reverse this imbalance could prevent or control high blood pressure and translate into fewer heart attacks, strokes, and deaths from heart disease. The ruptured cells leak their potassium into the sample. The most common cause is excessive potassium loss in urine due to prescription medications that increase urination. The probable lethal dose is between 15-30 grams. Br Med J. 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