PubMed:Toxicity of tributyltin and triphenyltin to early life-stages of Paracentrotus lividus (Echinodermata: Echinoidea). We examined the effect of tributyltin (TBT) on the sex differentiation process in genetically female Japanese flounder (Paralichthys olivaceus).The fish were fed an artificial diet containing tributyltin oxide (TBTO) at concentrations of 0.1 and 1.0 μg/g diet from 35 to 100 d after hatching, which includes the sex differentiation period. Neat tributyltin oxide (TBTO) was purchased from Sigma-Aldrich and used to prepare a The effects of tributyltin (TBT) to the life cycle of the estuarine fish Cyprinodon variegatus were examined in a 180-day flow-through exposure. ENVIRONMENTAL TOXICITY DATA FOR CHEMICALS LISTED UNDER EPCRA SECTION 313 CAS NO. PubMed:[Soil sorption of bis-(tributylin) oxide]. Human data summarized by Boyer (1989) suggest that tributyltin oxide is a potent non-allergenic dermal irritant. The acute inhalation toxicity of Bio-Met-5, bis-tri-n-butyltin-oxide (56359) (Bio-Met-TBTO), tributyltin-fluoride (1983104) (TBTF) and tributyltin-benzoate (4342363) (TBTB) was investigated in Charles-River-rats. The acute 96-hour LC50 to freshwater fish ranged from 2.6 µg/L to 13 µg/L. Its chemical formula is [ ( and Anobium punctatum (Deg.) After 6-8 h, swelling of mitochondria appeared in the secretory cells of the sweat glands. Previous studies have indicated that TBTO can cause immunotoxicity as an environ-mental pollutant. TBTO was shown to be hazardous to nontarget organisms. The toxic effects of bis (tributyltin) oxide (TBTO) on the rat liver were studied with an electron microscope and the accumulation sites of tin were determined with an X-ray microanalyzer. 7th World Meeting ORTEP Ass., J.A. There are no data in humans concerning development of cancer following exposure to tributyltin oxide (TBTO). The enclosed Reregistration For sperm cells, the toxicity of the two tributyl compounds was significantly greater than that of two triphenyl compounds; for embryos, the triphenyl compounds appeared to be more toxic. LC50s range from 6 to 240 ugl TBT. Tributyltin oxide (TBTO) has been widely used as marine antifouling composition, preservative, biocide, and a stabilizer in plastic industry. Male Wistar rats received an intramuscular injection of 0.5 ml/kg bis (tributyltin) oxide. These workers also showed that dibutyltin, the major metabolite of tributyltin, is less effective in inducing apoptosis in vitro, suggesting that the in vivo toxicity is directly attributable to tributyltin. Comparative toxicity of tributyltin-oxide (TBTO) for fish and snail. The present study was carried out to investigate the acute toxicity of TBTO and the effects of its sublethal concentration on brain AChE and gill ATPases activity of tilapia fish, Oreochromis niloticus during acute (3-96 h) and subchronic (7-28 d) exposure periods. Tributyltin (TBT), an organotin compound, is hazardous in aquatic ecosystems. The acute toxicity of tributyltin compounds has been studied on several species of freshwater fish. Toxicity values (mean effective concentration [EC50]) ranged from 2.97 to 18.5 μg/L for sperm cells and from 1.11 to 2.62 μg/L for embryos. CCME (1991 Appendix X) summarised the toxicity data for tributyltin for freshwater animals. The Physico-chemical and Physiological Bases of Tributyltin Uptake by Mussels, Mytilus. No developmental effects of nTiO2 were observed at 2 mg/L but concentrations ≥10 mg/L caused hatching inhibition and malformations. 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