2010;42(7):1375-1387. Kumada, T., Nishii, R., Higashi, T., Oda, N., and Fujii, T. Epileptic apnea in a trisomy 18 infant. Huck, N. O., McBride, S. A., Kendall, A. P., Grugle, N. L., and Killgore, W. D. The effects of modafinil, caffeine, and dextroamphetamine on judgments of simple versus complex emotional expressions following sleep deprivation. Stroke. University of Bristol, School of Chemistry Web Site. View abstract. J Pediatr.Psychol. 2014 Mar;17(3):625-33. doi: 10.1017/S1368980013000360. Holick, C. N., Smith, S. G., Giovannucci, E., and Michaud, D. S. Coffee, tea, caffeine intake, and risk of adult glioma in three prospective cohort studies. Epub 2012 26. Steer, P., Flenady, V., Shearman, A., Charles, B., Gray, P. H., Henderson-Smart, D., Bury, G., Fraser, S., Hegarty, J., Rogers, Y., Reid, S., Horton, L., Charlton, M., Jacklin, R., and Walsh, A. Int J Epidemiol. Arch.Pediatr.Adolesc.Med. Hartley SL, Barbot F, Machou M, Lejaille M, Moreau B, Vaugier I, Lofaso F, Quera-Salva MA. View abstract. Aviat.Space Environ Med 2007;78(9):871-877. J Sleep Res 10-14-2010; View abstract. Pharmacol Rep. 2009;61(5):819-826. Epub 2013 26. View abstract. Antonelli-Ushirobira, T. M., Kaneshima, E. N., Gabriel, M., Audi, E. A., Marques, L. C., and Mello, J. C. Acute and subchronic toxicological evaluation of the semipurified extract of seeds of guarana (Paullinia cupana) in rodents. View abstract. Caffeine is not listed as having a drug interaction with the atypical antipsychotic medicine Vraylar (generic name: cariprazine). Caballero, T., Garcia-Ara, C., Pascual, C., Diaz-Pena, J. M., and Ojeda, A. Urticaria induced by caffeine. Ker, K., Edwards, P. J., Felix, L. M., Blackhall, K., and Roberts, I. Caffeine for the prevention of injuries and errors in shift workers. 2016 26;5(1). N.Engl.J Med 7-17-1980;303(3):122-124. Potential toxicity of caffeine when used as a dietary supplement for weight loss. Appl Physiol Nutr Metab. Kockler DR, McCarthy MW, Lawson CL. J Sports Sci 2010;28(8):833-842. Mostofsky, E., Schlaug, G., Mukamal, K. J., Rosamond, W. D., and Mittleman, M. A. Caffeine as an analgesic adjuvant for acute pain in adults. J Psychopharmacol. Greenway FL, Raum WJ, DeLany JP. Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. Bonsignore A, Sblano S, Pozzi F, Ventura F, Dell'Erba A, Palmiere C. A case of suicide by ingestion of caffeine. View abstract. Smits, P., Lenders, J. W., and Thien, T. Caffeine and theophylline attenuate adenosine-induced vasodilation in humans. View abstract. Hsu, C., Harden, R. N., and Houle, T. Nicotine and caffeine intake in complex regional pain syndrome. Weng X, Odouli R, Li DK. Rahnama, N., Gaeini, A. J Clin Pharmacol 1999;39:936-40. 2010;25(4):310-317. Clin Pharmacol Ther 1989;45:234-40. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. View abstract. Epub 2013 7. Caffeine is used therapeutical … View abstract. Med.Sci.Sports Exerc. A., Rowson, M. J., and De Bruin, E. A. View abstract. View abstract. View abstract. 2006;30(2):112-4. Available for Android and iOS devices. View abstract. Benowitz NL, Osterloh J, Goldschlager N, et al. Am J Clin Nutr 2010;91:73-81. Walker, T. B., Balldin, U., Fischer, J., Storm, W., and Warren, G. L. Acceleration tolerance after ingestion of a commercial energy drink. Coffee, caffeine, and risk of depression among women. View abstract. Greenwood, D. C., Alwan, N., Boylan, S., Cade, J. E., Charvill, J., Chipps, K. C., Cooke, M. S., Dolby, V. A., Hay, A. W., Kassam, S., Kirk, S. F., Konje, J. C., Potdar, N., Shires, S., Simpson, N., Taub, N., Thomas, J. D., Walker, J., White, K. L., and Wild, C. P. Caffeine intake during pregnancy, late miscarriage and stillbirth. Int J Obes Relat Metab Disord 1994;18:99-103. Ryu, J. E. Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants. View abstract. Giving caffeine early to very premature infants does not allow them to be weaned from a ventilator faster than giving them caffeine right before being weaned. Brown, S. L., Salive, M. E., Pahor, M., Foley, D. J., Corti, M. C., Langlois, J. View abstract. West J Med 1992;157:544-53. Schrader P, Panek LM, Temple JL. Int.J.Sport Nutr. Wilson RE, Kado HS, Samson R, Miller AB. Dipyridamole (Persantine) is often used by doctors to do a test on the heart. 2014;168(3):250-7. doi: 10.1001/jamapediatrics.2013.4371. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Biol.Psychol. Chen, J. F. and Chern, Y. Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies. Irwin, C., Desbrow, B., Ellis, A., O'Keeffe, B., Grant, G., and Leveritt, M. Caffeine withdrawal and high-intensity endurance cycling performance. View abstract. Higginbotham, E. J., Kilimanjaro, H. A., Wilensky, J. T., Batenhorst, R. L., and Hermann, D. The effect of caffeine on intraocular pressure in glaucoma patients. 2020. View abstract. View abstract. Peliowski, A. and Finer, N. N. A blinded, randomized, placebo-controlled trial to compare theophylline and doxapram for the treatment of apnea of prematurity. Caffeine and miscarriage risk. Psychopharmacology (Berl) 1997;129:1-14. View abstract. Potential toxicity of caffeine when used as a dietary supplement for weight loss. Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. View abstract. Appetite 2010;54(2):406-409. Caffeine can be habit-forming. View abstract. 2014 Apr 4. Astorino, T. A., Terzi, M. N., Roberson, D. W., and Burnett, T. R. Effect of caffeine intake on pain perception during high-intensity exercise. Purpose Caffeine makes people more alert, less drowsy, and improves coordination. View abstract. Cases.J 2009;2:6612. Pediatrics 2009;123(6):e1005-e1010. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. Voskoboinik A, Kalman JM, Kistler PM. Müller SA, Rahbari NN, Schmied BM, Büchler MW. View abstract. The use of caffeine in adolescents and adults with ADHD has not been studied. Epub 2013 27. Li, Z., Liu, W., Mo, B., Hu, C., Liu, H., Qi, H., Wang, X., and Xu, J. Caffeine overcomes genistein-induced G2/M cell cycle arrest in breast cancer cells. We comply with the HONcode standard for trustworthy health information -, Caffeine Use in Pregnancy & Breastfeeding, caffeine Oral, Parenteral Advanced Consumer, Caffeine; Caffeine and Sodium Benzoate Injection; Caffeine Citrate Monograph. Eur.J.Pediatr. Taking caffeine by mouth in combination with pain relievers is effective for treating tension headaches. View abstract. The effect of caffeine on postprandial hypotension in the elderly. View abstract. Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Caffeine-containing medicines increase the risk of hemorrhagic stroke. 2005;37(11):1998-2005. Geriatr Gerontol Int. View abstract. 2000;31(5):562-568. 2002 Feb;25:364-9. J Sports Sci. Muscle Nerve 2011;43(6):839-844. Coffee, tea, and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis. View abstract. 2014 Sep;10(3):448-51. doi: 10.1007/s12024-014-9571-6. Doherty, M. The effects of caffeine on the maximal accumulated oxygen deficit and short-term running performance. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Alstott, R. L., Miller, A. J., and Forney, R. B. Many varieties of tea contain caffeine. Med Sci Sports Exerc. J Am Coll Nutr. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 3 Dec 2020) and others. Last updated on May 28, 2020. View abstract. Low-dose caffeine may exacerbate psychotic symptoms in people with schizophrenia. Henderson-Smart, D. J. and Davis, P. G. Prophylactic methylxanthines for extubation in preterm infants. View abstract. Bellar, D., Kamimori, G. H., and Glickman, E. L. The effects of low-dose caffeine on perceived pain during a grip to exhaustion task. Caffeine might also speed up the nervous system. Am.J.Clin.Nutr. View abstract. Altern Med Rev 2005;10(4):321-325. Taking a single 6 mg dose of caffeine by mouth seems to improve walking and muscle strength in people with aching and cramping due to narrowed or blocked arteries. View abstract. Garrett, B. E. and Griffiths, R. R. Physical dependence increases the relative reinforcing effects of caffeine versus placebo. View abstract. Ann Neurol. Diener, H. C., Pfaffenrath, V., Pageler, L., Peil, H., and Aicher, B. View abstract. Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance. Rhee J, Kim R, Kim Y, et al. Cardiology in the Elderly 1994;2(6):499-503. Liu, W. H. and Chang, L. S. Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway. J Laryngol Otol 1999;113:341-5. View abstract. View abstract. View abstract. View abstract. Effects on blood pressure of drinking green and black tea. If you are pregnant, discuss with your health care provider if caffeine is appropriate for your use. Eur J Nutr. 2020;12(2):434. Research on the effects of caffeine in people with type 1 diabetes is inconsistent. Kennedy, D. O. and Haskell, C. F. Cerebral blood flow and behavioural effects of caffeine in habitual and non-habitual consumers of caffeine: a near infrared spectroscopy study. View abstract. Cochrane.Database.Syst.Rev. Acta Paediatr.Scand. Int.J.Epidemiol. Although caffeine might help prevent type 2 diabetes, it might not be effective in treating type 2 diabetes. Drugs Aging 2001;18(11):797-806. Henderson-Smart, D. J. and Steer, P. Doxapram versus methylxanthine for apnea in preterm infants. 1997;25(11):1298-1303. Part 182 -- Substances Generally Recognized As Safe. Caffeine is a commonly consumed psychoactive drug which produces its psychomotor stimulant and reinforcing effects through antagonism at adenosine receptors and indirect effects on dopaminergic neurotransmission.1 Consumption of caffeine at recommended dietary doses is not generally associated with negative health consequences,2 and caffeine has some clinical utility, such as for enhancement of analgesia.3 However, there is also evidence that some caffeine consumers might experience caffeine-r… Seek medical attention right away if any of these severe side effects occur: This is not a complete list of all side effects that may occur. N.Engl.J.Med. View abstract. View abstract. View abstract. Caffeine intake enhances the benefits of sodium glucose transporter 2 inhibitor. View abstract. A double blind trial. A., Donatelli, M., Tranchina, M. R., Belmonte, S., Mattina, A., Re, A., and Cerasola, G. Acute effects of coffee on endothelial function in healthy subjects. Ruusunen, A., Lehto, S. M., Tolmunen, T., Mursu, J., Kaplan, G. A., and Voutilainen, S. Coffee, tea and caffeine intake and the risk of severe depression in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. View abstract. Int J Neurosci. View abstract. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. 1988 ; 6 ( 4 ):167-172 processes on development of exertional rhabdomyolysis in three Army... Nutr cancer 2008 ; 12 ( 9 ):871-877 the psychostimulant effects of oxcarbazepine, lamotrigine tiagabine! Citrate of potassium or sodium -- can help breathing in very premature infants E. M., Houck P.. Taurine on simulated laparoscopy performed following sleep deprivation: a cross-cultural comparison dipyridamole Persantine. 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